Early stage screening of Alzheimer's disease by detecting subtypes of MCI...with a normal webcam POC.
A reliable and inexpensive diagnostic test that can be used in any doctor's office all over the world....
AI 4.0...A decision making tool for GP's ( General Practitioner )
Identification of clusters of rapid and slow decliners among subjects at risk for Alzheimer’s disease.
Dragan Gamberger, Nada Lavrač, Shantanu Srivatsa, Rudolph E. Tanzi, P. Murali Doraiswamy Scientific Reports, 2017; 7
There are more than 10.000 diseases and only 200-300 symptoms....
What we try to do is...looking after more symptoms with digital biomarkers...symtoms that you can't see but what we can detect with new computer technologies and AI...
The reason why 99,6% of all Alzheimer's drugs fail...even with neurons without any plaques...we still have an old neuron with low neuroplasticity with no to low communication...for giving energy to old neurons...we use an active component of Curcumin JL56-51... in development ( Nature.com ) https://www.nature.com/articles/s41598-018-19154-y
....to see what you can't see...we can see with AI...
ALZHEIMER's IS ASSOCIATED WITH A SYNAPTIC DYSFUNCTION RATHER THAN THE DISAPPEARANCE OR SYNAPTIC DESTRUCTION...this change therapeutic approach...http://www.douglas.qc.ca
Alzheimer's disease is a heterogenous condition with high individual variability in age of onset, rate of clinical decline as well as degree of underlying pathology..
What can machine learning and big data mean for AD ?
Big data is the fundamental building block of machine learning
Big data, is, essentially, exactly what it's called: a ton of data. Algorithms sort through this vast collection of information so that technology can predict what we'll do next.Machine learning is all about sorting through those troves of collected information to discern patterns and predict new ones
According to researchers, adult born neurons play a critical role in the identification of sensory stimulus and the positive values associated with sensory experience. Institute Pasteur
Although we have known for several years that the adult brain can produce new neurons, many questions about the properties conferred by these adult-born neurons were left unanswered. What advantages could they offer that could not be offered by the neurons generated shortly after birth...
Scientists from the Institut Pasteur and the CNRS have demonstrated that the new neurons produced in adults react preferentially to reward-related sensory stimuli and help speed up the association between sensory information and reward. Adult-born neurons therefore play an important role in both the identification of a sensory stimulus and the positive value associated with that sensory experience. The neurons generated shortly after birth are unable to perform this function.
These findings are published in the journal PNAS on February 19, 2018.
The future of medicine is based in data and analytics
Deep Learning - DL
DL is an algorithmic technique modeled after the neural structures in human brains. The term is sometimes referred to as “neural networks” because researchers were inspired by the synapses and neurons in the human brain and the mechanism by which neurons fire and cause synapses to collect and propagate the energy of that neuron.
Curcumin improves memory and mood, new UCLA study says...American Journal of Geriatric Psychiatry 22 Jan. 2018
The double-blind, placebo-controlled study involved 40 adults between the ages of 50 and 90 years who had mild memory complaints. Participants were randomly assigned to receive either a placebo or 90 milligrams of curcumin twice daily for 18 months.“These results suggest that taking this relatively safe form of curcumin could provide meaningful cognitive benefits over the years,” said Small, UCLA’s Parlow–Solomon Professor on Aging..
Bioavailability is very important...Curcumin Plus 27 X available Feb/ March 2018 for Europe...
Curcumin market 2016-2024
Mild Cognitive Impairment or MCI
MCI causes a slight but noticeable and measurable decline in cognitive abilities, including memory and thinking skills. Long-term studies suggest that 15-20 percent of the aged 65 and older may have MCI. There is a difference between normal aging cognitive decline and MCI. With all kind of rating scales it is not possible to see any difference.
Biomarkers for Alzheimer's disease can be really measured to indicate the presence or absense of the disease. For AD there is only one biomarker accepted amyloid beta. Preclinical b. amyloid as biomarker is difficult and very expensive to detect and it is only possible in hospitals. Digital biomarkers can be used outside the hospital POC ( in the waiting room or at home).
Blood glucose levels are a biomarker for diabetes and blood cholesterol for heart disease.
T: +32 11 397523
M: 0497 21 93 40
PET amyloid = hospital
Not available in all places
Expert reader training
Monitoring not possible
Lab to lab variability
Full alignment of standarization of technique for CFS collection not obtained
NO standardization of assay
Not invasive = NO PAIN
No radiation exposure
Accurate diagnosis is needed for Dementia Lewy Body
Dementia with Lewy Bodies (DLB) may account for up to 30% of all dementia cases. The symptoms of DBL can be difficult to disentangle from other dementia subtypes. DLB is characterized by a build-up of abnormal proteins (Lewy bodies) in areas that control cognition, movement, allertness and behavior.
Eye tracking ( saccadic eye movement tracking) and EEG are very sensitive digital biomarkers to make an accurate diagnosis.
AD and DLB pathologies often overlap within individuals. An individual is diagnosed with Parkinson disease dementia ( PDD) or DLB depends on the timing of symptoms onset. In dementia with Lewy Bodies, cognitive decline occurs within one year of the onset of movement disorder symptoms.
DLB is sensivity to antipsychotic drugs. We see also REM behavior disorder. Visual hallucinations and fluctuations in cognition, attention and allertness.
Centrum Zuid 1111
Tel: +32 11 397523
Mob: 0497 219340
These are the most commonly misdiagnosed conditions.
It is a degenerative disorder of the central nervous system with symptoms including tremors in hands, arms or legs, stiff muscles, and problems with balance or walking.
However, it is commonly mistaken for Alzheimer’s disease, stroke, stress, a traumatic head injury and essential tremor.
The condition causes an overactive thyroid gland, and is the most common cause of hyperthyroidism.
Symptoms include eyes bulging, anxiety, sweating, rapid pulse, unplanned weight loss or gain, and extreme tiredness.
Without treatment, it can prove life-threatening, however it is often mistaken for depression, ageing and under-exercising.
It is a chronic arthritis-like disorder characterised by widespread pain.
However, symptoms - anxiety, sensitivity to pain and incapacitating fatigue - can be confused with rheumatoid arthritis and chronic fatigue syndrome.
Normal pressure hydrocephalus
It is a build-up of cerebrospinal fluid in the brain that most commonly occurs after a stroke or ahead injury from a fall.
Symptoms of unsteady gait, progressive dementia and urinary problems, can be interpreted as Alzheimer’s disease or Parkinson’s disease.
The progressive autoimmune disease that attacks the central nervous system has symptoms including muscle spasms, lack of coordination, balance problems, blurred vision and cognitive impairment.
However, it is commonly mistaken for a viral infection, lupus, Alzheimer’s disease and bipolar disorder.
It is an autoimmune disorder marked by an inability to digest gluten, a protein in wheat, rye and barley.
Symptoms can include vomiting, abdominal pain and bloating, diarrhoea, weight loss, anaemia and leg cramps.
However it can be mistaken for irritable bowel syndrome, Crohn’s disease and cystic fibrosis
Chronic fatigue syndrome
The complex disorder has no known cause but symptoms include loss of memory or concentration, a sore throat, painful lymph nodes in neck or armpits, unexplained muscle or joint pain and extreme exhaustion.
It is often confused with sinus problems, hepatitis, fibromyalgia, lupus and rheumatoid arthritis.
It is a chronic inflammatory disease, with symptoms including fatigue, kidney, heart and lung damage, rash and joint pain.
However, it can be mistaken for chronic fatigue syndrome, fibromyalgia and rheumatoid arthritis.
This is where a tear develops in the aorta, the largest blood vessel branching from the heart, which causes the inner and middle layers to separate.
Symptoms can include sudden chest or upper back pain, loss of consciousness, shortness of breath, sweating and weak pulse in one arm.
However it can be misdiagnosed as heartburn, heart attack and stroke.